A difficult endocrinological patient in oncological practice. Own clinical obseration

Klinefelter syndrome is a genetic disease in males (1 per 1000 newborns) due to the presence of doubled X chromosome karyotype (47XXY karyotype), most common cause primary hypogonadism. It characterized by polymorphism clinical manifestations, which are male infertility, obesity, metabolic syndrome, type 2 diabetes mellitus, osteopenia and osteoporosis. Clinical variability leads development associated conditions against background changes hormonal regulation observation different specialists, as result late diagnosis syndrome. Endogenous hypercorticism 2030 % caused Itsenko Cushing's structure about 7080 unilateral adrenal adenomas (corticosteromas). ACTH-independent number cardiovascular disorders, including abdominal arterial hypertension, steroid diabetes, Long-term suppression ACTH, according feedback principle, secretion hormones pituitary endocrine glands (including sex steroids). The illustrates complex pathophysiological disorders that occur when hypothalamic-pituitary-adrenal / gonadal axis disturbed combination two syndromes, well importance comprehensive examination endocrinological patients.